Prague in the Czech Republic is a very popular European tourist destination and is located 700km south-east from Amsterdam.
Let's look at the options for travel between these 2 cities by air, train and bus. Note that Prague is known as Praag (in Dutch) and Praha (in Czech).
1. Amsterdam-Prague by Air
Flights between Amsterdam Schiphol (AMS) and Prague Václav Havel Airport Airport (PRG) take around 90 minutes flying time - certainly the quickest way to travel. Dutch airline KLM has up to 4 daily non-stop flights from Amsterdam to Prague using either its "Cityhopper" Embraer 190 or Boeing 737 aircraft.
KLM's Skyteam partner CSA Czech Airlines flies 2x daily non-stop flights (morning and evening) between Amsterdam and Prague using Airbus A319 aircraft.
KLM and CSA return fares are priced from €100 return.
Alternatives: No-frills airline Easyjet flies up to 10x weekly from AMS to PRG - expect to pay €100 return for an advance booking that includes checked luggage.
Transavia (a KLM no-frills subsidiary) flies 6x weekly from Eindhoven airport (EIN) to Prague - prices from about €100 return including checked luggage fees.
Other airlines that serve Amsterdam and Prague are Lufthansa (via Frankfurt), Austrian (via Vienna), Swiss (via Zurich), British Airways (via London) and Alitalia (via Milan).
2. Amsterdam-Prague by Train
As of 2015, the direct Amsterdam to Prague City Night Line (CNL) overnight train no longer serves Amsterdam. Instead it operates (almost) daily from Cologne to Prague via Düsseldorf, Berlin and Dresden.
This means passengers from Amsterdam need to travel to Cologne by ICE train and connect onto the CNL train. Total journey time is just under 15 hours using the fastest train connections.
For example, passengers could take either the 1635 or 1835 ICE train service from Amsterdam Central which arrive in Cologne at 1912 and 2112, respectively. From there the Prague-bound City Night Line train departs at 2313 with main stops at Düsseldorf (2337), Duisburg (2353), Dortmund (0032), Berlin Hbf (0653) and Dresden (0858). The train arrives in Prague at 1128 the following morning.
In the opposite direction the CNL train departs Prague daily at 1827 and includes stops at Dresden (2107), Berlin Hbf (2359), Dortmund (0531), Duisburg (0609), Düsseldorf (0631) before reaching Cologne at 0656 the next day. There is an ICE train departing Cologne at 0844 which arrives in Amsterdam at 1127.
You will need to buy separate tickets for the ICE and City Night Line. ICE one way fares (Amsterdam to Cologne) start at €19 (2nd class) and €39 (1st class).
One-way prices for the City Night Line start at €43 for seat only, €59 for a couchette and up to €134 for a deluxe 2 bed sleeper with ensuite facilities.
Alternatively, the journey can be done from Amsterdam during the day via Germany by using the following combinations:
Amsterdam to Berlin: Take the morning IC service from Amsterdam Central to Berlin HBf which takes around 6 1/2 hours. Prices start from €39 one-way.
Berlin to Prague: There are up to 6 daily EuroCity services between Berlin and Prague - plus an evening EuroNight train which goes on to Vienna. This EuroCity journey takes around 4 hours 30 minutes and is priced from €29 (2nd class) or €49 (1st class) one-way. The EuroNight train takes just over 5 hours.
A faster alternative rail-bus route is to take the daily ICE service (direction Basel) from Amsterdam Central to Mannheim station. From there take the rail "Express Bus" service to Prague via Nürnberg. Total journey time takes just over 11 hours. To secure the lowest fares you need to split the ticket via Germany and book well in advance.
3. Amsterdam-Prague by Coach
Flixbus-Meinfernbus is a German bus company that operates a 2x daily bus service (1 daytime and 1 overnight) from Amsterdam Sloterdijk station to Prague (central bus station ÚAN Florenc). The journey takes around 13 hours and prices start at €39 one-way. Click here to book with Flixbus
Eurolines runs a 4x weekly overnight coach service from its Amsterdam Duivendrecht terminal to Prague central bus station. The journey takes approximately 14 hours and singles start from around €34.
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