Frankfurt in Germany is one of Europe's major financial hubs and is located approximately 350km south-east from Amsterdam. Netherlands and Germany are both in the Schengen zone so passport controls are not necessary.
There are various travel options between the 2 cities - train, air and coach (bus)...
1. Amsterdam-Frankfurt by Train
The best way to travel between Amsterdam and Frankfurt is by rail. Modern ICE International trains run up to 7x daily from Amsterdam central station to Frankfurt airport and Frankfurt Hauptbahnhof (main station) - the journey takes just 3h 55mins.
The train makes stops in Utrecht, Arnhem, Düsseldorf and Köln (Cologne). The ICE runs at speeds of up to 300km/h on the Cologne-Frankfurt section.
The lowest one-way fare in 2nd class for the trip is €39, though availability is somewhat limited and fares of €49 to €69 are more common. Consider checking the 1st class price which can be had from €69 one-way.
Travelling by ICE train on this route is certainly far more comfortable and convenient than either air or bus travel.
For more info see International Rail Services to/from Amsterdam
2. Amsterdam-Frankfurt by Air
The 2 respective "national" carriers operate services between Amsterdam Schiphol (AMS) and Frankfurt Main International airport (FRA). Flight time is scheduled to be around 65 minutes.
KLM (Skyteam) flies a 5x daily Cityhopper service between Amsterdam and Frankfurt using Embraer jets. Prices start from around €110 return not including checked luggage.
Lufthansa (Star Alliance) operates 5x daily on the Amsterdam-Frankfurt flight route using Airbus A320 series aircraft.
Return fares are similar to those offered by KLM.
KLM and Lufthansa are the only viable options on this short flight route - you could also fly Air France (via Paris), British Airways (via London) or Czech Airlines (via Prague) - but these would be significantly more inconvenient as well as expensive.
3. Amsterdam-Frankfurt by Coach
German coach company Flixbus operates up to 6x direct coach service daily from Amsterdam Sloterdijk to Frankfurt Main Hauptbahnhof. The coaches take about 6 hours and singles start from around €25.
Eurolines runs a 10x weekly coach service from its Amsterdam Duivendrecht terminal to Frankfurt HauptBahnhof. The journey takes approximately 8 hours - choose between day and overnight services. Singles start at €19.
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